FACTORES IMPLICADOS EN LA ALOPECIA: TGF-b (MICROINFLAMACION)

En cierto porcentaje con alopecia androgenetica se ha detectado un infiltrado inflamatorio entorno al folículo, parar esa microinflamacion es uno de los objetivos que se debe marcar todo tratamiento contra la alopecia androgenetica, mi proposito en este post es exponer uno de los factores implicados en el proceso: tgf-b (factor beta transformador del crecimiento) miembro de una superfamilia de factores polipeptídicos ,que son potentes inhibidores del crecimiento e inductores de apoptosis de un gran número de tipos celulares, incluyendo células epiteliales, endoteliales y hematopoyéticas.

básicamente la acción de esta citoquina es la desregulacion de las fases del ciclo celular,(quizá de ahí venga que la fase anagena del cabello se acorte)Se ha demostrado que el TGF- b inhibe las actividades de los complejos ciclina D-Cdk4/6 y ciclina E/Cdk2 (reguladores del ciclo celular), ,también inicia la cascada de las caspasas, que son las responsables ultimas de la apoptosis o suicidio celular.

TGF- b induce también un proceso de estrés oxidativo, se ha comprobado como la producción de radicales de oxígeno precede a una bajada en el potencial de membrana mitocondrial y a la liberación del citocromo c desde la mitocondria, eventos que se han descrito en aquellos procesos de apoptosis donde la mitocondria juega un papel activo.

Este factor puede ser combatido con ciertos antioxidantes, de ahí el beneficio de algunos extractos herbales tipo te verde.

ISOTRETINOINA

Nos encontramos con un fármaco destinado a luchar contra el acné, normalmente se recurre a el si este es grave, ya sea vía oral o tópica.
A diferencia de otros retinoides como el adapaleno, este fármaco si cura algunos tipos de acné, actuando sobre el receptor de retinoides y degradando el receptor de androgenos.
Se elimina vía orina advirtiéndose una coloración verde-amarilla, teniendo una vida media de 30 horas aprox.
Los efectos que notaremos en el organismo con mayor rapidez es una disminución de la secreccion sebácea cutánea.
En todo momento hay que decir que este fármaco afecta a la estructura de la piel de forma que debemos protegernos de los rayos del sol.
La via topica es mas económica que la oral, pero provoca inflamacion y escozor con facilidad.

La vía mas inteteresante, y mas cara es la oral que suele ser prescrita por facultativos en ciclos de cuatro meses.  Presenta el problema de que al ser un derivado de la vitamina a, puede dañar el higado, de ahí que se desaconseje el consumo de bebidas alcohólicas conjunto a su toma.

Algunos efectos secundarios que podemos notar son los siguientes:

• labios enrojecidos, resquebrajados y doloridos
• sequedad de la piel, ojos, boca o nariz
• hemorragia (sangrado) nasal
• cambios en el color de la piel
• descamación de la piel, especialmente en las palmas de las manos y plantas de los pies
• cambios en las uñas
• lenta curación de los cortes o heridas
• hemorragia o hinchazón de las encías
• pérdida del cabello o crecimiento de vello en lugares no deseados
• transpiración
• rubor
• cambios de la voz
• cansancio
• síntomas de resfrío

ECLIPTA ALBA Y ALOPECIA ANDROGENETICA

Sin mucho ruido nos llega la noticia de que esta hierba, puede ser una nueva  vía de estudio, o una alternativa a lo ya existente para tratar la alopecia androgenética.
Hay varios estudios que lo confirman el primero parece hecho en ratones, donde comparándolo con el minoxidil hizo crecer pelo más rápido que éste.
En el segundo se nos muestra como actúa (al menos en parte), incrementando los niveles de el factor de los fibroblastos 7 (FGF-7), el cual tiene un rol en la angiogenesis, la creación y mantenimiento de vasos sanguineos, y bajando los niveles de BMP-4, ambos factores implicados en la alopecia androgenetica.
En el tercero se utiliza un grupo control al que se aplica minoxidil y a otro un preparado herbal entre el que esta la Eclipta Alba además de Citrullus colocynthis y Cuscuta Reflexa, y las hierbas obtienen un resultado positivo en cabellos en fase anágena.

Hair growth promoting activity of Eclipta alba in male albino rats.

Roy RK, Thakur M, Dixit VK.

Department of Pharmaceutical Sciences, Dr HS Gour University, Sagar, MP, India.

Abstract

Alopecia is a dermatological disorder with psychosocial implications on patients with hair loss. Eclipta alba Hassk. is a well-known Ayurvedic herb with purported claims of hair growth promotion. In the reported work attempts were undertaken to evaluate petroleum ether and ethanol extract of E. alba Hassk. for their effect on promoting hair growth in albino rats. The extracts were incorporated into oleaginous cream (water in oil cream base) and applied topically on shaved denuded skin of albino rats. The time (in days) required for hair growth initiation as well as completion of hair growth cycle was recorded. Minoxidil 2% solution was applied topically and served as positive control for comparison. Hair growth initiation time was significantly reduced to half on treatment with the extracts, as compared to control animals. The time required for complete hair growth was also significantly reduced. Quantitative analysis of hair growth after treatment with petroleum ether extract (5%) exhibited greater number of hair follicles in anagenic phase (69 +/- 4) which were higher as compared to control (47 +/- 13). The result of treatment with 2 and 5% petroleum ether extracts were better than the positive control minoxidil 2% treatment.


 Eclipta alba extract with potential for hair growth promoting activity.

Datta K, Singh AT, Mukherjee A, Bhat B, Ramesh B, Burman AC.

Molecular Oncology Lab., Dabur Research Foundation, Sahibabad, Ghaziabad 201010, India.

Abstract

ETHNOPHARMACOLOGICAL RELEVANCE: Eclipta alba is traditionally known to potentiate hair growth promotion.
AIM OF THE STUDY: The study was aimed to investigate the efficacy of methanol extract of Eclipta alba as hair growth promoter.
MATERIALS AND METHODS: Pigmented C57/BL6 mice, preselected for their telogen phase of hair growth were used. In these species, the truncal epidermis lacks melanin-producing melanocytes and melanin production is strictly coupled to anagen phase of hair growth. The extract was applied topically to assess telogen to anagen transition. Immunohistochemical investigation was performed to analyze antigen specificity. Animals in anagen phase of hair growth were positive for FGF-7 and Shh and negative for BMP4, whereas the animals in telogen phase were positive only for BMP4 antigen.
RESULTS: The methanol extract of whole plant when tested for hair growth promoting potential, exhibited dose dependent activity in C57BL6 mice. The activity was assessed by studying the melanogenesis in resected skin, follicle count in the subcutis, skin thickness and surrogate markers in vehicle control and extract treated animals.
CONCLUSION: These findings suggest that methanol extract of Eclipta alba may have potential as a hair growth promoter.

Development and evaluation of polyherbal formulation for hair growth-promoting activity.

Roy RK, Thakur M, Dixit VK.

Department of Pharmaceutical Sciences, Dr. H.S. Gour University, Sagar, Madhya Pradesh, India.

Abstract

BACKGROUND: Cuscuta reflexa (Roxb.), Citrullus colocynthis (Schrad.), and Eclipta alba (Hassk.) are traditionally acclaimed herbs for their hair growth-promoting potential. Aim In the present study, it was envisaged to prepare herbal formulations containing petroleum ether extracts of the three herbs in varying ratio and evaluating the formulations for the hair growth-promoting activity.
METHODS: The formulations as well as minoxidil (2%) solution (positive control) were applied topically on shaved skin of rats, and the time required for initiation and completion of hair growth cycle was recorded.
RESULTS AND CONCLUSIONS: Hair growth initiation time was markedly reduced to one third on treatment with the prepared formulation compared with control animals. The time required for complete hair growth was also reduced by 32%. Quantitative analysis of hair growth cycle after treatment with formulations and minoxidil (2%) exhibited greater number of hair follicles in anagenic phase compared with control. The results thus corroborate with the traditionally acclaimed hair growth-promoting capabilities of the plants. The prepared formulation also holds potential for treatment of alopecia.

LA VITAMINA C POTENCIA EL EFECTO ANTIOXIDANTE DEL TE VERDE

El mero hecho de añadir jugo de cítricos (limón, naranja etc.) a la infusión de te verde (Camellia sinensis) se ha demostrado que potencia el efecto de los antioxidantes de la planta.
El te verde es consumido en todo el mundo, y a muchos de sus amantes además de gustarle su sabor ponen como razón principal de ingesta sus propiedades anti-aging.
Los componentes químicos responsables de estos efectos son las llamadas catequinas: flavonoides con propiedades anticancerigenas, antiradicalares y reductoras de la grasa acumulada, sobre todo en el abdomen.
El beneficio de la adicción de la vitamina c es por que en el estómago se aumenta la biodisponibilidad de las catequinas, por ende pasa mayor cantidad de este componente a sangre.
En un estudio parece ser que las catequinas disponibles aumentaron un 80% con la adicción de jugo de limón.
Aquí tenemos el estudio:

Common tea formulations modulate in vitro digestive recovery of green tea catechins : Rodney J. Green¹, Angus S. Murphy², Burkhard Schulz²,Bruce A. Watkins¹, Mario G. Ferruzzi.

 Abstract

Epidemiological evidence suggests a role for tea catechins in reduction of chronic disease risk. However, stability of catechins under digestive conditions is poorly understood. The objective of this study was to characterize the effect of common food additives on digestive recovery of tea catechins. Green tea water extracts were formulated in beverages providing 4.5, 18, 23, and 3.5 mg per 100 mL epicatechin (EC), epigallocatechin (EGC), epigallocatechin-gallate (EGCG), and epicatechin-gallate (ECG), respectively. Common commercial beverage additives; citric acid (CA), BHT, EDTA, ascorbic acid (AA), milk (bovine, soy, and rice), and citrus juice (orange, grapefruit, lemon, and lime) were formulated into finished tea beverages at incremental dosages. Samples were then subjected to in vitro digestion simulating gastric and small intestinal conditions with pre- and post-digestion catechin profiles assessed by HPLC. Catechin stability in green tea was poor with < 20% total catechins remaining post-digestion. EGC and EGCG were most sensitive with ⪇ 10% recovery. Teas formulated with 50% bovine, soy, and rice milk increased total catechin recovery significantly to 52, 55, and 69% respectively. Including 30 mg AA in 250 mL of tea beverage significantly (p < 0.05) increased catechin recovery of EGC, EGCG, EC, and ECG to 74, 54, 82, and 45% respectively. Juice preparation resulted in the highest recovery of any formulation for EGC (81–98%), EGCG (56–76%), EC (86–95%), and ECG (30–55%). These data provide evidence that tea consumption practices and formulation factors likely impact catechin digestive recovery and may result in diverse physiological profiles.

LI CHING-YUN. EL HOMBRE MAS LONGEVO DE LA HISTORIA

El New York Times nos trajo su historia y con ella nacía un mito, el de un hombre en extremo longevo. Según este periódico este hombre podría haber vivido la friolera de 256 años.
Parece una cifra exagerada si lo comparamos con la mujer más longeva de la historia, una Francesa que apenas llegó a la segunda década pasados los cien.
Una cifra exagerada según algunos, cuyas dudas se ven falsadas en parte por los documentos felicitación por  su 100 y 150 cumpleaños. Su única foto parece haber sido tomada a los 250.

La bruma parece cernirse sobre los primeros años de vida, de la que lo poco que se sabe es que la pasó en el medio rural, que tuvo una buena alfabetización, y que viajó de forma incansable.

UNA VIDA RELACIONADA CON LA MEDICINA Y LA SALUD.
Li fue un experto en hierbas medicinales, las cuales recolectaba el mismo. Además practicaba Tao y meditación en general.
La vitalidad de este hombre no paso inadvertida a sus coetáneos, y a las preguntas sobre como se debía vivir el respondía filosóficamente:

“Mantén un corazón tranquilo,
Siéntate como una tortuga,
camina rápido como una paloma
y duerme como un perro.”

 Pero obviamente este no podía ser su único secreto, su dieta era baja en calorías, y estaba compuesta por varios tipos de arroces y el vino que se hacia a partir de éste. Nada fuera de lo común hasta aquí, lo realmente interesante viene ahora: manifestó consumir ginseng y  la hierba Centella Asiatica (Hydrocotyl asiática).
Todo esto sonó a chiste en la ciencia de la época, pero posteriores investigaciones revelaron el potencial de algunas sustancias de esta hierba, en varias afecciones y contra el envejecimiento (acido aciaticoside, madecasoside...).

PEELING QUIMICO

El peeling consiste en atacar las capas superficiales de la piel, con productos irritantes o corrosivos para que se renueve la piel, luciendo las nuevas células mucho mejor.
Hay dos tipos de peeling: químico y físico, en el presente artículo nos ocuparemos del primero.
Tras estos tratamientos podemos esperar un cutis mas terso, firme, sin manchas y con un aspecto mejor en general.


Algunos agentes de este tipo pueden ayudar en afecciones como acné, acné rosácea, y otras afecciones cutáneas o atenuar cicatrices.
Tras la aplicación de estas sustancias suele mejorar la producción de colágeno y elastina.
Según la profundidad que se pretenda conseguir en la renovación de la piel, se puede clasificar.
Hay varias sustancias que se pueden utilizar según lo que se busque:

• Ácido Glicolico: El mas popular, según la concentración se puede obtener mayor o menor profundidad (6- 40%).  Al ser un ácido es irritante. Actúa colándose entre las células y disolviendo el tejido conectivo, a diferencia, como el resto, de los keratoliticos que actúan sobre la keratina. Se pueden obtener buenos resultados.


• Ácido Tricloroacetico: Mas orientado a borrar daños en la piel (cicatrices, quemaduras etc.). También se puede utilizar como despigmentante. Se usa en una concentración de entre diez a veinte por ciento. Como el glicólico es un ácido y por ello puede irritar.


• Fenol o Ácido Carbólico : se utiliza en concentración de alrededor del 80%, se usa cuando se busca profundidad. Deja la piel muy clara. Para arrugas serias, piel envejecida etc.

Estos tratamientos deben ser administrados por un experto. Es normal que después de su aplicacion notemos, ardor cutáneo, escozor, picor etc.
No es recomendable tomar el sol tras ello ni la administración de agentes keratoliticos ni irritantes. Es recomendable usar cremas hidratantes.

SAW PALMETTO, ESTUDIOS DE ALOPECIA

La Serenoa Serrulata  o Serenoa Repens  ha sido calificada muchas veces como ineficaz o incluso de timo, por ello me he propuesto en este articulo hacer una recopilación de los estudios existentes relevantes en cuanto a mejora de la salud o tratamiento de afecciones. Quizá conozcas alguno que no este, no tienes más que sugerirlo en un comentario y lo añadiré agradecido. La aplicación que nos interesa es la alopecia androenética y derivados.
Siento que los estudios estén en inglés,pero no he podido encontrarlos en Español. Aqui tenemos una revision completa sobre la hierba Serenoa: Revision sobre Saw Palmetto

Prager N, Bickett K, French N, Marcovici G.
A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.  
BACKGROUND: Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Furthermore, AGA has also been shown to be responsive to drugs and agents used to treat BPH. Of note, certain botanical compounds have previously demonstrated efficacy against BPH. Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of AGA.
OBJECTIVES: The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and beta-sitosterol, in the treatment of AGA. Subjects: Included in this study were males between the ages of 23 and 64 years of age, in good health, with mild to moderate AGA.
RESULTS: The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit.
CONCLUSIONS: This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials.

 Chittur S, Parr B, Marcovici G. 
Inhibition of Inflammatory Gene Expression in Keratinocytes Using a Composition Containing Carnitine, Thioctic Acid and Saw Palmetto Extract. 

Chronic inflammation of the hair follicle (HF) is considered a contributing factor in the pathogenesis of androgenetic alopecia (AGA). Previously, we clinically tested liposterolic extract of Serenoa repens (LSESr) and its glycoside, beta-sitosterol, in subjects with AGA and showed a highly positive response to treatment. In this study, we sought to determine whether blockade of inflammation using a composition containing LSESr as well as two anti-inflammatory agents (carnitine and thioctic acid) could alter the expression of molecular markers of inflammation in a well-established in vitro system. Using a well-validated assay representative of HF keratinocytes, specifically, stimulation of cultured human keratinocyte cells in vitro, we measured changes in gene expression of a spectrum of well-known inflammatory markers. Lipopolysaccharide (LPS) provided an inflammatory stimulus. In particular, we found that the composition effectively suppressed LPS-activated gene expression of chemokines, including CCL17, CXCL6 and LTB(4) associated with pathways involved in inflammation and apoptosis. Our data support the hypothesis that the test compound exhibits anti-inflammatory characteristics in a well-established in vitro assay representing HF keratinocyte gene expression. These findings suggest that 5-alpha reductase inhibitors combined with blockade of inflammatory processes could represent a novel two-pronged approach in the treatment of AGA with improved efficacy over current modalities.

Potency of a novel saw palmetto ethanol extract, SPET-085, for inhibition of 5alpha-reductase II.  Pais P.

METHODS: The aim of the present study was to determine the in vitro potency of a novel saw palmetto ethanol extract (SPET-085), an inhibitor of the 5alpha-reductase isoenzyme type II, in a cell-free test system. On the basis of the enzymatic conversion of the substrate androstenedione to the 5alpha-reduced product 5alpha-androstanedione, the inhibitory potency was measured and compared to those of finasteride, an approved 5alpha-reductase inhibitor.

RESULTS: SPET-085 concentration-dependently inhibited 5alpha-reductase type II in vitro (IC(50)=2.88+/-0.45 microg/mL). The approved 5alpha-reductase inhibitor, finasteride, tested as positive control, led to 61% inhibition of 5alpha-reductase type II.
CONCLUSION: SPET-085 effectively inhibits the enzyme that has been linked to BPH, and the amount of extract required for activity is very low compared to data reported for other extracts. It can be concluded from data in the literature that SPET-085 is as effective as a hexane extract of saw palmetto that exhibited the highest levels of bioactivity, and is more effective than other SPEs tested. This study confirmed that SPET-085 has prostate health-promoting bioactivity that also corresponds favorably to that reported for the established prescription drug standard of therapy, finasteride.

A Randomized, Double-Blind, Placebo-Controlled Trial to Determine the Effectiveness of Botanically Derived Inhibitors of 5-α-Reductase in the Treatment of Androgenetic Alopecia
Nelson Prager, Karen Bickett, Nita French, Geno Marcovici. The Journal of Alternative and Complementary Medicine. April 2002,

Background: Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-α reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Furthermore, AGA has also been shown to be responsive to drugs and agents used to treat BPH. Of note, certain botanical compounds have previously demonstrated efficacy against BPH. Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of AGA.

Objectives: The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and β-sitosterol, in the treatment of AGA.
Subjects: Included in this study were males between the ages of 23 and 64 years of age, in good health, with mild to moderate AGA.
Results: The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit.

Conclusions: This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials. 

Clinical and instrumental study of the efficacy of a new sebum control cream

1. Department of Dermatology, Medical University, Plovdiv, Bulgaria

Background  Some botanical compounds are considered useful to reduce sebum production.

Aim  To evaluate the efficacy of a sebum control cream containing polyphenol-rich extract from saw palmetto, sesame seeds, and argan oil in subjects with oily facial skin.

Methods  The study was carried out during the winter months (January and February). A total of 20 healthy volunteers (9 male and 11 female, aged 17–50 years, 16 with oily skin and 4 with combined skin) were studied. The test product was applied twice daily to the face for a period of 4 weeks. A clinical assessment and instrumental measurements were done before and after the treatment period. Casual sebum level on the forehead and both cheeks was determined with a photometric device (Sebumeter®). The quantity of sebum on the midforehead was determined using sebum collector foils (Sebufix®), which were then evaluated with skin camera Visioscope® and software SELS (Surface Evaluation of the Living Skin). A subjective evaluation questionnaire regarding the cosmetic characteristics, tolerance, and efficacy of the product was filled out by the volunteers at the end of study.

Results  The product was very well accepted by all the volunteers. A visible sebum-regulating efficacy was reported in 95% of them. After 4 weeks of treatment, the clinical assessment scores decreased by 33%. There was a significant reduction in the casual sebum level by 20% and area covered with oily spots by 42%. The number of active sebaceous glands remained unaltered.

Conclusion  These results objectively and quantitatively show the efficacy of the sebum control cream tested to reduce the greasiness and improve the appearance of oily facial skin

A randomized, double-blind, placebo-controlled trial to determine the effectiveness of botanically derived inhibitors of 5-alpha-reductase in the treatment of androgenetic alopecia.

Prager N, Bickett K, French N, Marcovici G.

Clinical Research and Development Network, Aurora, CO, USA.

BACKGROUND: Androgenetic alopecia (AGA) is characterized by the structural miniaturization of androgen-sensitive hair follicles in susceptible individuals and is anatomically defined within a given pattern of the scalp. Biochemically, one contributing factor of this disorder is the conversion of testosterone (T) to dihydrotestosterone (DHT) via the enzyme 5-alpha reductase (5AR). This metabolism is also key to the onset and progression of benign prostatic hyperplasia (BPH). Furthermore, AGA has also been shown to be responsive to drugs and agents used to treat BPH. Of note, certain botanical compounds have previously demonstrated efficacy against BPH. Here, we report the first example of a placebo-controlled, double-blind study undertaken in order to examine the benefit of these botanical substances in the treatment of AGA.
OBJECTIVES: The goal of this study was to test botanically derived 5AR inhibitors, specifically the liposterolic extract of Serenoa repens (LSESr) and beta-sitosterol, in the treatment of AGA. Subjects: Included in this study were males between the ages of 23 and 64 years of age, in good health, with mild to moderate AGA.
RESULTS: The results of this pilot study showed a highly positive response to treatment. The blinded investigative staff assessment report showed that 60% of (6/10) study subjects dosed with the active study formulation were rated as improved at the final visit.
CONCLUSIONS: This study establishes the effectiveness of naturally occurring 5AR inhibitors against AGA for the first time, and justifies the expansion to larger trials.
 Effectiveness of Serenoa Repens on Androgenetic Alopecia
C. Fasulo, A. Linguiti, L. Bosco, P. Morganti, R. A. Satriano

Aim: the aim of this double blinded study was to evaluate the activity performed by 3 different cosmetic formulations especially enriched with Serenoa Repens extract with a known quantity of total sterols on the hair growth and serbum secretion.
Method: 34 men and 28 women, aged 18-48 were divided into 3 groups using the products for 3 months.
The first group used all 3 products enriched with Serenoa repens extract, the second of all 3 products (placebo free of Serenoa repens extract), and the third group use used shampoo and lotion enriched with Serenoa repens extract, but dietary supplement placebo.
Results: the results showed a significant 35% hair increase both on number and mass, and a contemporary 67% decrease superficial sebum in the 1st group.
Group 3 revealed a hair increase of 20% with a contemporary decrease of deborrhea 35%. . Group 2 had no results.
Conclusions: this study confirms effectiveness of Serenoa repens extract on hair baldness such as androgenetic alopecia, especially when connected with 5 alpha reductase activity.